Tesofensine

Tesofensine is a next-generation appetite suppressant that works by targeting three key brain chemicals: serotonin, norepinephrine, and dopamine. Originally developed by NeuroSearch A/S in Denmark for Parkinson’s and Alzheimer’s, it now helps reduce hunger and improve satiety. Within about two weeks, users notice a decrease in appetite, better control over cravings, and increased fat burning. Tesofensine also improves insulin sensitivity, boosting glucose metabolism, and raises overall energy usage. The drug has a long half-life of 8–9 days and is mainly metabolized in the liver to its main metabolite, M1.

Key Effects:

• Suppresses appetite and increases fullness

• Promotes fat oxidation and reduces body fat

• Enhances insulin sensitivity and glucose use

• Alters dopaminergic receptor activity in the brain

• Increases energy expenditure